"The people in Toronto really appreciate films," Lee said. "Toronto's a great vehicle, a great launch pad for the film to come out in the fall."
The festival runs through Sept. 13 with a lineup that includes the Coen brothers' comedy "Burn After Reading" with George Clooney and Brad Pitt.
Related Story: Brad Pitt And George Clooney In "Burn After Reading" - Early Review And Movie Trailer
Also previewing will be Keira Knightley's historical saga "The Duchess", Edward Norton and Colin Farrell's cop drama "Pride and Glory", and the supernatural romantic comedy "Ghost Town," with Ricky Gervais, Tea Leoni and Greg Kinnear.
Related Story: New "Ghost Town" Movie Trailer - Tea Leoni Cancels Toronto Trip
Lee's "Miracle at St. Anna" is due in theaters September 26. The film chronicles the story of four black American soldiers who are members of the US Army as part of the all-black 92nd Buffalo Soldier Division stationed in Tuscany, Italy during World War II.
They experience the tragedy and triumph of the war as they find themselves trapped behind enemy lines and separated from their unit after one of them risks his life to save an Italian boy.
Watch Spike Lee's "Miracle at St. Anna" Movie Trailer
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